4 edition of Chalones: a tissue-specific approach to mitotic control found in the catalog.
Chalones: a tissue-specific approach to mitotic control
John C. Houck
Includes bibliographical references.
|Statement||[by] John C. Houck [and] Wayne F. Daugherty.|
|Series||Medcom medical update series|
|Contributions||Daugherty, Wayne F., 1938- joint author.|
|LC Classifications||QP572.C47 H68|
|The Physical Object|
|Pagination||xi, 59 p.|
|Number of Pages||59|
|LC Control Number||73021867|
Jonathan Bard (Emeritus Professor, University of Edinburgh) has worked on all aspects of developmental anatomy (models. morphogenesis, anatomical ontologies and the origins of anatomical variation. O H Iversen's 46 research works with citations and reads, including: [Sedimentation rate and renal cancer].
Progression through meiosis: the role of CDK-cyclin complexes. Progression through the mitotic cell cycle has been found to rely on quantitative and qualitative aspects of CDK-cyclin complexes (Fig. 3 a). On the one hand, it has been found that oscillating levels of kinase activity drive the advancement in the cell cycle—a major regulator of this oscillation is the APC/C (see next chapter).Cited by: selective control of organ growth. When a significant part of the liver of a rat is removed, the remaining tissue is quickly triggered to regenerate via mitotic cell growth. The same process can happen with the kidney and certain other organs. Hepatectomized rats somehow know that their liver-to-body ratio is abnormally low and respond by the.
- Control of the Cell Cycle. Leland Hartwell (born ), Fred Hutchinson Cancer Research Center, Seattle, USA, is awarded for his discoveries of a specific class of genes that control the cell cycle. One of these genes called "start" was found to have a central role in controlling the first step of each cell cycle. Britton, J. S. & Edgar, B. A. Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms. Development , Cited by:
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Get this from a library. Chalones: a tissue-specific approach to mitotic control. [John C Houck; Wayne F Daugherty]. Control of cell proliferation is executed, in part, by means of negative feedback, utilizing cell-line specific messenger substances called chalones. Although knowledge of chalone chemistry is still in its infancy, the reality of the concept can no longer be reasonably by: In a number of tissues It has been found that mitotic activity is controlled by specific mitotic inhibitors, called by: Abstract.
Everyone who has followed the development of our field during the past 20 years has to acknowledge, willingly, and with gratitude, how valuable, perhaps irreplaceable in this particular instance, the approach has been to connect the sparse fact by persistent hypothesizing and constructing a unifying vision, the true nature of which we may hope to know only in the distant future.
Abstract. Chalones are auto-inhibitory factors which control tissue growth by reducing cell multiplication. To belong to this class of factors, a product extracted from blood or organs has to meet the following conditions: (1) It acts specifically on one type of cells, (2) the same cells produce the factor and are sensitive to it, and (3) the factor is truly involved in the physiological Cited by: The effects of fractions (Chalones) obtained from lymphoid organs on lymphocyte proliferation in vitroCited by: Organized into three parts, this book begins with the physiological significance of chalones.
This class of hormones is intimately associated with mitotic homeostasis as inhibitors of cell division. The book then looks into the aspects of blood cell formation and release, as well as the humoral control of organs and tissue Edition: 1. The striking biological characteristics of chalones are (i) they are produced by the tissues on which they act, (2) they inhibit mitotic activity both in vivo and in vitro, (3) their action is reversible and (4) they are not species- or by: Tests on surviving cultures of bone marrow cells from rats with experimental polycythemia showed that the chalone activity of, erythrocytic chalone is considerably reduced in the presence of phytohemagglutinin (PHA).
The chalone depresses the agglutinating activity of PHA on bone marrow cells. Adsorption of the chalone preparation on immobilized PHA leads to disappearance of Author: G.
Neustroev, N. Korolev. 3 The Control of Mitotic Division I. Introduction II. The Cell Biological Approach to the Study of Mitosis III.
The Genetic Approach IV. The Biochemical Approach V. The Immunological Approach VI. The Current Model for Mitotic Regulation References 4 Cell Cycle and Cell-Growth Control I. Introduction: A Historical Overview of the Cell Cycle Edition: 1. Number 20 Citation Classics Bullough W S. Mitotic and functional homeostasis: a speculative review.
Cancer Res. This review put forward a new concept of the control of tissue growth by mitotic inhibitors, called chalones. Slowly this concept has become generally accepted, and it has also proved to have a. However, the precise mechanism of chalones as a specific endogenous mitotic inhibitor is still unclear.
Recently, chalones have been isolated and purified from adult bovine hearts(2). Analytical ultracentrifugation of the highly purified fraction indicated a sedimentation coefficient of s and a molecular weight of by: 1.
Author(s): Houck,John C; Daugherty,Wayne F, Title(s): Chalones: a tissue-specific approach to mitotic control [by] John C. Houck and Wayne F. Daugherty, Jr. Country of Publication: United States Publisher: [New York] Medcom Press [c] Description: xi, 59 p.
illus. Language: English ISBN:LCCN: MeSH: Growth Inhibitors*; Mitosis* NLM ID: [Book]. Aqueous extracts of calf and pig lymphoid organs were prepared and fractionated by means of gel filtration, ion exchange chromatography, and isoelectric focusing.
These fractions, which had been previously assessed on mitogen-stimulated mouse spleen lymphocytes and other cells in vitro, were tested for their in vivo activity on humoral (haemolytic PFC in mice) and on cell-mediated Cited by: 4.
purpose. This approach is especially obvious in the chapter on the role of chalones in carcinogenesis where such ‘supportive’ references are gleaned from the ’s.
The book is peppered with scientific errors - thick epithelia with high mitotic rates can indeed. Chalones and a great selection of related books, art and collectibles available now at Imidazole acetate, a histamine breakdown product, was found to be a striking mitotic M was also a strong mitotic inhibitor.
This finding is directly opposed to that in rat skin where mitosis is stimulated. Imidazole acetate, a histamine breakdown product, was found to be a striking mitotic stimulator Cited by: The changes imposed on the nucleus, chromatin and its regulators during mitosis lead to the dismantlement of most gene regulatory processes.
However, an increasing number of transcriptional regulators are being identified as capable of binding their genomic targets during mitosis. These so-called ‘mitotic bookmarking factors’ encompass transcription factors and chromatin modifiers that are Cited by: Chalones are tissue-specific secreted proteins that control organ size [ 50 ].
It is thought that each organ can secrete a distinct chalone that circulates through the body and inhibits the growth of that specific tissue. In many cases, these are N-substituted oligopeptides that can regulate genes involved in growth and differentiation [ 51 ].Cited by: Replacement of the N-methyl of trigonelline with an ethyl group, 8, gives an analogue possessing only weak activity.
The steric requirement of the pyridine ring is not as critical. The quinoIine derivative, 13, has reduced activity, but at high concentrations the proportions of cells arrested in G2 approach the levels induced by by:.
Diseases of the skin. Present and future trends in approaches to skin disease Tissue-specific. chalones. may. was a disease of faulty epidermopoiesis due to impaired auto-control.Professor W.
S. Bullough, professor of Zoology, Birkbeck College, London, who first suggested the existence of chalones inexplained to delegates at an International Chalone Symposium in Lane End, Bucks, last week, that chalones are anti-mitotic substances produced intra- cellularly which inhibit further growth when tissues have reached.
Histone H3 was used as a chromatin loading control and PH3S10 indicates mitotic chromatin. All scale bars, 10 μm. Data are means of at least three independent by: